By George M. Rodgers
This accomplished quantity discusses the protease ADAMTS13, summarizing the present prestige of uncomplicated and medical study. The 9 authoritative chapters commence with a historic viewpoint through exploration of the biochemistry and structure-function relationships of ADAMTS13 in addition to its general functionality in hemostasis (cleavage of von Willebrand factor). rising learn issues for ADAMTS13 are lined, together with its capability function in angiogenesis and different facets of mobilephone biology. extra subject matters comprise laboratory assays for ADAMTS13, inherited ADAMTS13 deficiency, and purchased ADAMTS13 deficiency. A bankruptcy on similar thrombotic microangiopathic (TMA) issues examines the variations among TMAs linked to ADAMTS13 deficiency and people no longer linked to ADAMTS13 deficiency. a last bankruptcy reports the initial details on rising facets of ADAMTS13, equivalent to the prestige of recombinant ADAMTS13 items and their power utility.
Comprehensive in its exploration of the ADAMTS13 protease in disease, ADAMTS13: Biology and disorder is an important source for medical hematologists, transfusion drugs physicians, and researchers attracted to hemostasis, vascular biology, biochemistry, and metalloproteases.
Read Online or Download ADAMTS13: Biology and Disease PDF
Similar hematology books
VA scientific heart and the clinical collage of Georgia, Augusta. experiences equipment most beneficial for the analysis and administration of hematologic malignancies. tools are offered intimately for the professional researcher and the fewer skilled. DNLM: Lymphoma.
Animal welfare is attracting expanding curiosity around the globe, yet fairly from these in built nations, who now have the data and assets in an effort to increase the welfare of livestock. The elevated recognition given to farm animal welfare within the West derives principally from the truth that the relentless pursuit of ?
This ebook offers intimately with all points of the easiest perform in smooth radiotherapy for Hodgkin lymphoma. It offers the historical past and reason for the inclusion of radiotherapy in today’s combined-modality method, together with targeted medical events comparable to Hodgkin lymphoma in childrens, within the pregnant sufferer, and within the aged.
From an acclaimed writer within the box, it is a compelling learn of the origins and heritage of the ailment normally noticeable as afflicting younger single ladies. figuring out of the situation became puberty and virginity into health conditions, and Helen King stresses the continuity of this ailment via history,depsite huge, immense shifts in clinical figuring out and technonologies, and drawing parallels with the fashionable ailment of anorexia.
- Rare Lymphomas
- Venous Thrombosis in Women: Pregnancy, the Contraceptive Pill and Hormone Replacement Therapy
- Artificial Cells: Biotechnology, Nanomedicine, Regenerative Medicine, Blood Substitutes, Bioencapsulation, Cell/Stem Cell Therapy (Regenerative Medicine, Artificial Cells and Nanomedicine)
- A Martian Stranded on Earth: Alexander Bogdanov, Blood Transfusions, and Proletarian Science
- Allogeneic Stem Cell Transplantation (Current Clinical Oncology)
Extra resources for ADAMTS13: Biology and Disease
Rao C, Foernzler D, Loftus SK, Liu S, McPherson JD, Jungers KA, Apte SS, Pavan WJ, Beier DR. A defect in a novel ADAMTS family member is the cause of the belted whitespotting mutation. Development. 2003;130(19):4665–72. Silver DL, Hou L, Somerville R, Young ME, Apte SS, Pavan WJ. The secreted metalloprotease ADAMTS20 is required for melanoblast survival. PLoS Genet. 2008;4(2):1–15. Rodriguez-Manzaneque JC, Westling J, Thai SN, Luque A, Knauper V, Murphy G, Sandy JD, Iruela-Arispe ML. ADAMTS1 cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors.
Mosyak L, Georgiadis K, Shane T, Svenson K, Hebert T, McDonagh T, Mackie S, Olland S, Lin L, Zhong X, Kriz R, Reifenberg EL, Collins-Racie LA, Corcoran C, Freeman B, Zollner R, Marvell T, Vera M, Sum PE, Lavallie ER, Stahl M, Somers W. Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5. Protein Sci. 2008;17(1): 16–21. 46. Shieh HS, Mathis KJ, Williams JM, Hills RL, Wiese JF, Benson TE, Kiefer JR, Marino MH, Carroll JN, Leone JW, Malfait AM, Arner EC, Tortorella MD, Tomasselli A.
A typical furin processing site (Arg-Xaa-Arg/Lys-Arg) is present in all ADAMTS proteases but ADAMTS10 at the junction of the propeptide and catalytic module. ADAMTS10 has a suboptimal (Gly-Leu-Lys-Arg) site at the propeptide–catalytic module junction, but contains additional consensus sites within the propeptide . Whereas propeptide excision was not required for activity of ADAMTS9 and ADAMTS13 [23, 24], it is essential for activity of ADAMTS1, ADAMTS4, ADAMTS5, and ADAMTS15 [38–40, 43]. A structure of the ADAMTS13 catalytic domain is presently unavailable.
ADAMTS13: Biology and Disease by George M. Rodgers