By Alan Ebringer
Ankylosing spondylitis and Klebsiella is a entire and informative textual content at the reason behind Ankylosing spondylitis. Ankylosing spondylitis (AS) is a which impacts 20 million humans world wide and is probably going brought on or initiated by way of a bowel an infection from Klebsiella bacteria.
When a sufferer is contaminated by means of Klebsiella bacteria, his or her immune procedure will make antibodies opposed to all of the antigens or molecules present in the microbe. simply because many of the bacterial antigens resemble self tissues, the anti-bacterial antibodies will assault not just the micro organism but additionally the self tissues resembling the joints and the cells having an analogous HLA molecules, that is how the ailment AS begins. this can be the concept that of molecular similarity or “molecular mimicry” which formerly has been came across to paintings in different autoimmune ailments; rheumatic fever and rheumatoid arthritis.
The first paper in this topic was once released in 1976 and because thenover a hundred papers on rheumatological themes were released, from Prof Ebringer’s crew, on the department of existence Sciences, King’s university in London, united kingdom.
The correct details from those papers is extracted and offered during this ebook layout making it obtainable to well-being pros, study associations, pharmaceutical businesses and universities and most of the people.
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Additional info for Ankylosing spondylitis and Klebsiella
1899;15:45–57. Benedek TG. How did ankylosing spondylitis become a separate disease? Clin Exp Rheumatol. 2009;27 Suppl 55:S3–9. Buckley CW. Ankylosing spondylitis. In: Reports on chronic rheumatic diseases. London: Lewis; 1935. p. 77–89. Bywaters E. Historical perspectives in the aetiology of ankylosing spondylitis. Br J Rheumatol. 1983;27 Suppl 2:1–4. Chem RK, Schmit P, Fauré C. Did Rameses II really have ankylosing spondylitis ? A reappraisal. Can Assoc Radiol J. 2004;55:211–7. Fagge CH. A case of simple synostosis of the ribs to the vertebrae and of the arches and articular processes of the vertebrae themselves and also of one hip joint.
10 PostB-27 cells AntiKlebsiella serum Bacterial Agglutination Results The results of bacterial agglutination tests using the motile, flagellate microorganism Enterobacter aerogenes are summarised in Fig. 1. 025). However, studies with the non-motile microorganism Klebsiella pneumoniae failed to show any significant bacterial agglutination, even with rabbit Klebsiella antiserum. Ankylosing spondylitis patients were examined for the presence of the three microorganisms detected in the pilot study with serum obtained from rabbit A, namely, Enterobacter aerogenes, Klebsiella pneumoniae and Yersinia enterocolitica.
Lymphocytoxicity experiments have demonstrated that rabbit antisera raised against Klebsiella pneumoniae have greater cytotoxic activity against HLA-B27 lymphocytes obtained from ankylosing spondylitis patients than for non-B27 lymphocytes obtained from healthy subjects. Although these observations are compatible with cross-reactivity between HLAB27 lymphocytes and some antigens present in several species of Gram-negative microorganisms, such as Klebsiella or Yersinia, the cross-reactive peptides involved need to be identified.
Ankylosing spondylitis and Klebsiella by Alan Ebringer