By L. Heilmeyer, H. Begemann, Helmut Löffler, Johann Rastetter, Torsten Haferlach
This sixth version of the atlas has built-in the 2001 WHO type and made use of figures and outlines to rfile lately defined forms of leukemia and lymphoma. The latter comprise leukemias of dendritic cells, infrequent lymphomas and protracted polyclonal B lymphocytosis, which takes a distinct position within the classification.
The quantity covers the entire microscopic equipment in hematology that shape the foundation of analysis in addition to the result of glossy immunologic, cytogenetic and molecular-genetic research. certain emphasis is put on the cytogenetic and molecular-genetic characterization of organic entities that may shape the root for cutting edge therapies.
Normal effects and pathological findings are in comparison, and some of the findings made in the course of remedy are depicted. All in the entire Atlas of scientific Hematology represents an entire and necessary reference paintings which can be found in each hematologic and oncologic division in addition to in medical laboratories for on-line diagnostics and clinical research.
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Extra resources for Atlas of Clinical Hematology
Stomatocytes (Fig. 6 f) have a slitlike central lucency. They are found in the very rare hereditary stomatocytosis and in other anemias. Schizocytes (fragmentocytes) (Fig. 6 g) result from the fragmentation of erythrocytes, consisting either of a fragmented red cell or a fragment detached from such a cell. They resemble bits of broken egg shell. , in hemolytic uremic syndrome) as fast-flowing red cells are sliced apart by fibrin filaments. Siderocytes (Fig. 6 h) are erythrocytes that contain iron granules detectable with iron staining.
Clumps of chromatin may be found scattered among larger, chromatin-poor areas. Nucleoli are rarely present. 55 4 · Individual Cells Fig. 13 a – d a b c d IV 56 Chapter IV · Blood and Bone Marrow Fig.
Typically there is a perinuclear clear zone, which is found to contain minute granules on phase contrast examination. Hemoglobin first appears adjacent to the nucleus and produces a flaring of the perinuclear clear zone, later expanding to occupy the whole cell and heralding a transition to the polychromatic forms. Meanwhile the nucleus undergoes a characteristic structural change: the nucleoli disappear while the chromatin becomes coarser and acquires typical erythroblastic features. A continuum exists from the proerythroblasts to the basophilic erythroblasts (macroblasts) (Fig.
Atlas of Clinical Hematology by L. Heilmeyer, H. Begemann, Helmut Löffler, Johann Rastetter, Torsten Haferlach